The Role of Merlin/NF2 Loss in Meningioma Biology

The Role of Merlin/NF2 Loss in Meningioma Biology

Mutations in the <i>neurofibromin 2</i> (<i>NF2</i>) gene were among the first genetic alterations implicated in meningioma tumorigenesis, based on analysis of neurofibromatosis type 2 (NF2) patients who not only develop vestibular schwannomas but later have a high incidence...

Full description

Bibliographic Details
Main Authors:	Sungho Lee, Patrick J. Karas, Caroline C. Hadley, James C. Bayley V, A. Basit Khan, Ali Jalali, Alex D. Sweeney, Tiemo J. Klisch, Akash J. Patel
Format:	Article
Language:	English
Published:	MDPI AG 2019-10-01
Series:	Cancers
Subjects:	meningioma merlin neurofibromin 2 next-generation sequencing dream complex
Online Access:	https://www.mdpi.com/2072-6694/11/11/1633

Similar Items

Expression of merlin, NDRG2, ERBB2, and c-MYC in meningiomas: relationship with tumor grade and recurrence
by: B.R. Ongaratti, et al.
Published: (2016-01-01)

Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target
by: Kayleigh Bassiri, et al.
Published: (2017-02-01)

The Potential of MLN3651 in Combination with Selumetinib as a Treatment for Merlin-Deficient Meningioma
by: Jade Lyons Rimmer, et al.
Published: (2020-06-01)

Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth
by: Marianne F. James, et al.
Published: (2008-02-01)

Somatic mutation landscape of a meningioma and its pulmonary metastasis
by: Yaran Du, et al.
Published: (2018-05-01)

The characterization of Merlin in the Middle Ages /
by: Kissam, Margaret Denslow.
Published: (1967)

El “sueño de Merlín” y los episodios novedosos de los Baladros impresos en 1498 y 1535 respecto a la Suite du Merlin Post-Vulgate conservada
by: Paloma Gracia
Published: (2013-10-01)

"Quels beste ce pooit estre" : Merlin et le bestiaire dans trois Suites du Merlin en prose : d'une poétique du personnage à une poétique du roman
by: Fuertes-Regnault, Lise
Published: (2016)

The e-MERLIN Data Reduction Pipeline
by: Megan Kirsty Argo
Published: (2015-01-01)

Merlin deficiency alters the redox management program in breast cancer
by: Mateus Mota, et al.
Published: (2021-04-01)

Merlin regulates signaling events at the nexus of development and cancer
by: Mateus Mota, et al.
Published: (2020-04-01)

The Interaction Between Mixed-Lineage Kinase 3 and the Tumor Suppressor Protein Merlin
by: Stewart, Amanda Michelle
Published: (2009)

Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition
by: Katharine A. Michie, et al.
Published: (2019-04-01)

Meningioma maligno Malignant meningioma
by: Yvei González Orlandi, et al.
Published: (2011-03-01)

Caracterización, tradición y fuentes caballerescas del personaje de Merlín en el "Quijote"
by: Daniel Gutiérrez Trápaga
Published: (2010-12-01)

Everolimus and Bevacizumab in the Management of Recurrent, Progressive Intracranial NF2 Mutated Meningioma
by: Vinay Mathew Thomas, et al.
Published: (2019-01-01)

The Role of Phosphoinositide Binding in Merlin Function
by: Mani, Timmy
Published: (2011)

Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis
by: Victoria A Robb, et al.
Published: (2003-08-01)

La Suite du Roman de Merlin éditée d'après un manuscrit du XVe siècle : (Paris, BNF, fr. 112)
by: Cretoiu, Elena
Published: (2014)

PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin
by: Wei L, et al.
Published: (2020-10-01)

Luna Mariscal, Karla Xiomara, El motivo literario en «El Baladro del sabio Merlín» (1498 y 1535). Con un índice de motivos de «El Baladro del sabio Merlín» (Burgos, 1498 y Sevilla, 1535), México, El Colegio de México, 2017. 451 pp. ISBN 978-607-628-193
by: Fernando Gómez Redondo
Published: (2018-12-01)

Will the Merlin disappear as a breeding species from Northern Belarus?
by: Vladimir V. Ivanovsky
Published: (2016-04-01)

PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin [Corrigendum]
by: Wei L, et al.
Published: (2020-10-01)

A hypothesis about the potential role of statin administration as adjuvant treatment in the management of Merlin-deficient tumors
by: Alexandros G. Brotis, MD, PhD, et al.
Published: (2014-03-01)

MiR-25-3p Serves as an Oncogenic MicroRNA by Downregulating the Expression of Merlin in Osteosarcoma
by: Rao H, et al.
Published: (2020-09-01)

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma
by: Tatsuhiro Sato, et al.
Published: (2018-03-01)

La integración del “sueño de Merlín” en la Istoria de las Bienandanzas e Fortunas de Lope García de Salazar
by: Penélope Cartelet
Published: (2017-10-01)

Texte et images des manuscrits du Merlin et de la Suite Vulgate : mise en cycle et poétique de la continuation ou suite et fin d'un roman de Merlin ?
by: Fabry-Tehranchi, Irène
Published: (2011)

Atypical meningioma
by: G. Iacob, et al.
Published: (2012-09-01)

Meningioma anaplásico Anaplastic meningioma
by: Arlines Alina Piña Tornés, et al.
Published: (2013-03-01)

Meningiomas císticos
by: J. F. M. Araújo, et al.
Published: (1993-11-01)

Documentos sobre Merlín al alcance de Ariosto
by: Paloma Galán Redondo
Published: (2006-10-01)

Functional Relationship between Merlin and the ERM Proteins
by: Hebert, Alan
Published: (2012)

Enriched expression of NF1 in inhibitory neurons in both mouse and human brain
by: Hyun-Hee Ryu, et al.
Published: (2019-06-01)

Merlin/NF2-Lin28B-let-7 Is a Tumor-Suppressive Pathway that Is Cell-Density Dependent and Hippo Independent
by: Hiroki Hikasa, et al.
Published: (2016-03-01)

Merlín nuevo: un dossier profético en la Castilla medieval
by: Francisco Bautista
Published: (2019-10-01)

Cystic meningioma
by: Vikas Maheshwari, et al.
Published: (2017-12-01)

TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling
by: Raj R. Malinda, et al.
Published: (2020-05-01)

Meningiomas múltiplos e neurofibromatose: relato de três casos
by: Mauro A. Oliveira, et al.
Published: (1993-06-01)

Sinonasal Tract Meningioma
by: Jonathan P. Rivera, et al.
Published: (2018-07-01)