Sera from patients with sepsis induce nitric oxide production in vascular smooth muscle cells

Background: Nitric oxide (NO) is an important physiological mediator of vascular tone and is involved in pathophysiology of septic shock. Although plasma nitrite is a stable end product of NO oxidation derived from endogenous NO, the plasma nitrite level is also easily affected by the intake of vari...

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Bibliographic Details
Main Authors: Hiroshi Fujita, Junji Tomiyama, Hideki Kudo, Ikuo Morita, Sei-itsu Murota
Format: Article
Language:English
Published: Hindawi Limited 2000-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/09629350020027591
Description
Summary:Background: Nitric oxide (NO) is an important physiological mediator of vascular tone and is involved in pathophysiology of septic shock. Although plasma nitrite is a stable end product of NO oxidation derived from endogenous NO, the plasma nitrite level is also easily affected by the intake of various foods, bacterial products and renal functional status.
ISSN:0962-9351
1466-1861