Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.

Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.

Exosome is an extracellular vesicle released from multivesicular endosomes and contains micro (mi) RNAs and functional proteins derived from the donor cells. Exosomal miRNAs act as an effector during communication with appropriate recipient cells, this can aid in the utilization of the exosomes in a...

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Main Authors: Fumiyasu Momose, Naohiro Seo, Yasushi Akahori, Shin-Ichi Sawada, Naozumi Harada, Toru Ogura, Kazunari Akiyoshi, Hiroshi Shiku
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4839687?pdf=render
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spelling doaj-912bde45f92241a39e45ce0e8ea076de2020-11-25T02:33:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015413410.1371/journal.pone.0154134Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.Fumiyasu MomoseNaohiro SeoYasushi AkahoriShin-Ichi SawadaNaozumi HaradaToru OguraKazunari AkiyoshiHiroshi ShikuExosome is an extracellular vesicle released from multivesicular endosomes and contains micro (mi) RNAs and functional proteins derived from the donor cells. Exosomal miRNAs act as an effector during communication with appropriate recipient cells, this can aid in the utilization of the exosomes in a drug delivery system for various disorders including malignancies. Differences in the miRNA distribution pattern between exosomes and donor cells indicate the active translocation of miRNAs into the exosome cargos in a miRNA sequence-dependent manner, although the molecular mechanism is little known. In this study, we statistically analyzed the miRNA microarray data and revealed that the guanine (G)-rich sequence is a dominant feature of exosome-dominant miRNAs, across the mammalian species-specificity and the cell types. Our results provide important information regarding the potential use of exosome cargos to develop miRNA-based drugs for the treatment of human diseases.http://europepmc.org/articles/PMC4839687?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Fumiyasu Momose
Naohiro Seo
Yasushi Akahori
Shin-Ichi Sawada
Naozumi Harada
Toru Ogura
Kazunari Akiyoshi
Hiroshi Shiku
spellingShingle Fumiyasu Momose
Naohiro Seo
Yasushi Akahori
Shin-Ichi Sawada
Naozumi Harada
Toru Ogura
Kazunari Akiyoshi
Hiroshi Shiku
Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
PLoS ONE
author_facet Fumiyasu Momose
Naohiro Seo
Yasushi Akahori
Shin-Ichi Sawada
Naozumi Harada
Toru Ogura
Kazunari Akiyoshi
Hiroshi Shiku
author_sort Fumiyasu Momose
title Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
title_short Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
title_full Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
title_fullStr Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
title_full_unstemmed Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types.
title_sort guanine-rich sequences are a dominant feature of exosomal micrornas across the mammalian species and cell types.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2016-01-01
description Exosome is an extracellular vesicle released from multivesicular endosomes and contains micro (mi) RNAs and functional proteins derived from the donor cells. Exosomal miRNAs act as an effector during communication with appropriate recipient cells, this can aid in the utilization of the exosomes in a drug delivery system for various disorders including malignancies. Differences in the miRNA distribution pattern between exosomes and donor cells indicate the active translocation of miRNAs into the exosome cargos in a miRNA sequence-dependent manner, although the molecular mechanism is little known. In this study, we statistically analyzed the miRNA microarray data and revealed that the guanine (G)-rich sequence is a dominant feature of exosome-dominant miRNAs, across the mammalian species-specificity and the cell types. Our results provide important information regarding the potential use of exosome cargos to develop miRNA-based drugs for the treatment of human diseases.
url http://europepmc.org/articles/PMC4839687?pdf=render
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