Nano-carriers and their drug release

• Main Authors: Deng Guang, Wang Xiyou, Zhou Zhiguo, Yang Shiping
• Format: Article
• Language: English
• Published: Academic Journals Center of Shanghai Normal University 2017-12-01
• Series: Journal of Shanghai Normal University (Natural Sciences)
• Subjects: nano-carriers; drug delivery; biomedicinee
• Online Access: http://qktg.shnu.edu.cn/zrb/shsfqkszrb/ch/reader/view_abstract.aspx?file_no=20170602&flag=1

One of the hottest fields in biomedicine research is to encapsulate drugs and release them in particular organs by using nano-platform.Because nanoparticles can enter most cancer cells easily and accumulate inside the cells,drug-loaded nanoparticles with targeting modification can help to increase the drug concentration in lesion position,enhancing the drug effects and reducing the toxicity.In general,drug-loaded nanoparticles release drugs by diffusion or erosion.There are many ways to stimulate the release of drugs from nanoparticles,including pH,enzyme,light,magnetism,and ultrasound responses.This article reviews the principle and recent advances of drug-loaded nanoparticles.