Cross-Species Transmission and Evolution of SIV Chimpanzee Progenitor Viruses Toward HIV-1 in Humanized Mice

The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species transmission is not well understood. Here we simulated the SIVcpz initial transmission to humans using humanized mice and followed the viral evolution during serial passages lasting more than a year. All three SIVcp...

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Bibliographic Details
Main Authors: Kimberly Schmitt, James Curlin, Leila Remling-Mulder, Ryan Moriarty, Kelly Goff, Shelby O’Connor, Mark Stenglein, Preston Marx, Ramesh Akkina
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01889/full