Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis

Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis

BACKGROUND: Many previous studies have evaluated the histopathological features of tumours as risk factors for postoperative recurrence in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). However, there have been few large studies investigating the relationship between cyclooxygena...

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Main Authors: Yi-Fu He, Juan Jin, Wei Wei, Yan Chang, Bing Hu, Chu-Shu Ji, Wei-Dong Jia, Xiao-Qiu Wang, Ke Chen, Jian Chen
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2010/872570
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spelling doaj-91187b9a6374446ebf702147e96966df2020-11-24T20:56:00ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002010-01-0124743544010.1155/2010/872570Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related CirrhosisYi-Fu He0Juan Jin1Wei Wei2Yan Chang3Bing Hu4Chu-Shu Ji5Wei-Dong Jia6Xiao-Qiu Wang7Ke Chen8Jian Chen9Institute of Clinical Pharmacology, Anhui Medical University Key Laboratory of Anti-inflammatory and Immune Pharmacology of the Education Ministry of China, ChinaInstitute of Clinical Pharmacology, Anhui Medical University Key Laboratory of Anti-inflammatory and Immune Pharmacology of the Education Ministry of China, ChinaInstitute of Clinical Pharmacology, Anhui Medical University Key Laboratory of Anti-inflammatory and Immune Pharmacology of the Education Ministry of China, ChinaInstitute of Clinical Pharmacology, Anhui Medical University Key Laboratory of Anti-inflammatory and Immune Pharmacology of the Education Ministry of China, ChinaDepartment of Medical Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, ChinaDepartment of Medical Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, ChinaDepartment of General Surgery, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, ChinaDepartment of Pathology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, ChinaDepartment of Pathology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, ChinaDepartment of Medical Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei, ChinaBACKGROUND: Many previous studies have evaluated the histopathological features of tumours as risk factors for postoperative recurrence in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). However, there have been few large studies investigating the relationship between cyclooxygenase-2 (COX-2) expression in non-cancerous regions of the liver and postoperative recurrence in the remnant liver, especially in HBV-related HCC.http://dx.doi.org/10.1155/2010/872570
collection DOAJ
language English
format Article
sources DOAJ
author Yi-Fu He
Juan Jin
Wei Wei
Yan Chang
Bing Hu
Chu-Shu Ji
Wei-Dong Jia
Xiao-Qiu Wang
Ke Chen
Jian Chen
spellingShingle Yi-Fu He
Juan Jin
Wei Wei
Yan Chang
Bing Hu
Chu-Shu Ji
Wei-Dong Jia
Xiao-Qiu Wang
Ke Chen
Jian Chen
Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis
Canadian Journal of Gastroenterology
author_facet Yi-Fu He
Juan Jin
Wei Wei
Yan Chang
Bing Hu
Chu-Shu Ji
Wei-Dong Jia
Xiao-Qiu Wang
Ke Chen
Jian Chen
author_sort Yi-Fu He
title Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis
title_short Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis
title_full Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis
title_fullStr Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis
title_full_unstemmed Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis
title_sort overexpression of cyclooxygenase-2 in noncancerous liver tissue increases the postoperative recurrence of hepatocellular carcinoma in patients with hepatitis b virus-related cirrhosis
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2010-01-01
description BACKGROUND: Many previous studies have evaluated the histopathological features of tumours as risk factors for postoperative recurrence in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). However, there have been few large studies investigating the relationship between cyclooxygenase-2 (COX-2) expression in non-cancerous regions of the liver and postoperative recurrence in the remnant liver, especially in HBV-related HCC.
url http://dx.doi.org/10.1155/2010/872570
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