In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)

In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)

In this study, GC-MS analysis has shown that whole plant hexane fraction of Achillea wilhelmsii (WHFAW) consists of 66 compounds which exhibited antileishmanial activity. Antileishmanial bioassay was the method used for determining antileishmanial activity. The inhibitory concentration (IC50) which...

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Main Authors: Jahangir Khan Achakzai, Muhammad Anwar Panezai, Abdul Manan Kakar, Basira Akhtar, Ali Akbar, Shahabuddin Kakar, Javed Khan, Nazima Yousaf Khan, Ghulam Mustafa Khan, Nizam Baloch, Muhammad Hashim Jan Khoso, Marina Panezai
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2019/5734257
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spelling doaj-91181e44803a4894982fa1c58722789e2020-11-25T02:14:08ZengHindawi LimitedJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/57342575734257In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)Jahangir Khan Achakzai0Muhammad Anwar Panezai1Abdul Manan Kakar2Basira Akhtar3Ali Akbar4Shahabuddin Kakar5Javed Khan6Nazima Yousaf Khan7Ghulam Mustafa Khan8Nizam Baloch9Muhammad Hashim Jan Khoso10Marina Panezai11Institute of Biochemistry, University of Balochistan, Quetta 87300, PakistanInstitute of Biochemistry, University of Balochistan, Quetta 87300, PakistanInstitute of Biochemistry, University of Balochistan, Quetta 87300, PakistanDepartment of Botany, University of Balochistan, Quetta 87300, PakistanDepartment of Microbiology, University of Balochistan, Quetta 87300, PakistanDepartment of Zoology, University of Balochistan, Quetta 87300, PakistanDepartment of Microbiology, Quaid-i-Azam University, Islamabad 45320, PakistanInstitute of Biochemistry, University of Balochistan, Quetta 87300, PakistanDepartment of Chemistry, University of Balochistan, Quetta 87300, PakistanDepartment of Chemistry, University of Balochistan, Quetta 87300, PakistanInstitute of Biochemistry, University of Balochistan, Quetta 87300, PakistanInstitute of Biochemistry, University of Balochistan, Quetta 87300, PakistanIn this study, GC-MS analysis has shown that whole plant hexane fraction of Achillea wilhelmsii (WHFAW) consists of 66 compounds which exhibited antileishmanial activity. Antileishmanial bioassay was the method used for determining antileishmanial activity. The inhibitory concentration (IC50) which was observed for whole plant hexane fraction of Achillea wilhelmsii (WHFAW) against parasitic and vector-borne disease, leishmaniasis, is 58.27 ± 0.52 μg/mL. For leishmanicidal assay, Leishmania major is the species used for analysis. Whole plant methanol extract of Achillea wilhelmsii (WMEAW) and whole plant aqueous fraction of Achillea wilhelmsii (WAFAW) exhibited no antileishmanial activity.http://dx.doi.org/10.1155/2019/5734257
collection DOAJ
language English
format Article
sources DOAJ
author Jahangir Khan Achakzai
Muhammad Anwar Panezai
Abdul Manan Kakar
Basira Akhtar
Ali Akbar
Shahabuddin Kakar
Javed Khan
Nazima Yousaf Khan
Ghulam Mustafa Khan
Nizam Baloch
Muhammad Hashim Jan Khoso
Marina Panezai
spellingShingle Jahangir Khan Achakzai
Muhammad Anwar Panezai
Abdul Manan Kakar
Basira Akhtar
Ali Akbar
Shahabuddin Kakar
Javed Khan
Nazima Yousaf Khan
Ghulam Mustafa Khan
Nizam Baloch
Muhammad Hashim Jan Khoso
Marina Panezai
In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)
Journal of Chemistry
author_facet Jahangir Khan Achakzai
Muhammad Anwar Panezai
Abdul Manan Kakar
Basira Akhtar
Ali Akbar
Shahabuddin Kakar
Javed Khan
Nazima Yousaf Khan
Ghulam Mustafa Khan
Nizam Baloch
Muhammad Hashim Jan Khoso
Marina Panezai
author_sort Jahangir Khan Achakzai
title In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)
title_short In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)
title_full In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)
title_fullStr In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)
title_full_unstemmed In Vitro Antileishmanial Activity and GC-MS Analysis of Whole Plant Hexane Fraction of Achillea wilhelmsii (WHFAW)
title_sort in vitro antileishmanial activity and gc-ms analysis of whole plant hexane fraction of achillea wilhelmsii (whfaw)
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2019-01-01
description In this study, GC-MS analysis has shown that whole plant hexane fraction of Achillea wilhelmsii (WHFAW) consists of 66 compounds which exhibited antileishmanial activity. Antileishmanial bioassay was the method used for determining antileishmanial activity. The inhibitory concentration (IC50) which was observed for whole plant hexane fraction of Achillea wilhelmsii (WHFAW) against parasitic and vector-borne disease, leishmaniasis, is 58.27 ± 0.52 μg/mL. For leishmanicidal assay, Leishmania major is the species used for analysis. Whole plant methanol extract of Achillea wilhelmsii (WMEAW) and whole plant aqueous fraction of Achillea wilhelmsii (WAFAW) exhibited no antileishmanial activity.
url http://dx.doi.org/10.1155/2019/5734257
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