The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling

The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling

Abstract Background A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in t...

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Bibliographic Details
Main Authors: Min Li, Jingmin Cheng, Yuan Ma, Heng Guo, Haifeng Shu, Haidong Huang, Yongqin Kuang, Tao Yang
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cancer Cell International
Subjects:
JMJD2A
Glioma
mTOR
Rapamycin
PDK1
Online Access:http://link.springer.com/article/10.1186/s12935-020-01177-z

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