p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability

p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability

p50 is a constitutively produced NF-κB subunit that modulates the response to DNA damage. Here, the authors show that activation of ATR during S phase induces p50 interaction with BARD1 resulting in p50 mono-ubiquitination, facilitating cell cycle progression and promoting chromosome integrity.

Bibliographic Details
Main Authors: Longtao Wu, Clayton D. Crawley, Andrea Garofalo, Jackie W. Nichols, Paige-Ashley Campbell, Galina F. Khramtsova, Olufunmilayo I. Olopade, Ralph R. Weichselbaum, Bakhtiar Yamini
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18838-2
Description
Summary:p50 is a constitutively produced NF-κB subunit that modulates the response to DNA damage. Here, the authors show that activation of ATR during S phase induces p50 interaction with BARD1 resulting in p50 mono-ubiquitination, facilitating cell cycle progression and promoting chromosome integrity.
ISSN:2041-1723

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