Inclusion Compound of Efavirenz and γ-Cyclodextrin: Solid State Studies and Effect on Solubility

Inclusion Compound of Efavirenz and γ-Cyclodextrin: Solid State Studies and Effect on Solubility

Efavirenz is an antiretroviral drug of widespread use in the management of infections with human immunodeficiency virus type 1 (HIV-1). Efavirenz is also used in paediatrics, but due to its very poor aqueous solubility the liquid formulations available resort to oil-based excipients. In this report...

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Bibliographic Details
Main Authors: Susana Santos Braga, Firas El-Saleh, Karyna Lysenko, Filipe A. Almeida Paz
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
cyclodextrin inclusion
solution-phase
solid state
antiretroviral
Online Access:https://www.mdpi.com/1420-3049/26/3/519

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