PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma

PI3K inhibitor treatment ameliorates the glucocorticoid insensitivity of PBMCs in severe asthma

Abstract Background Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development of GC insensitivity in chronic airway diseases. However, the underlying molecular mechani...

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Bibliographic Details
Main Authors: Jing Bi, Zhihui Min, Honglei Yuan, Zhilong Jiang, Ruolin Mao, Tao Zhu, Chunfang Liu, Yuzhen Zeng, Juan Song, Chunling Du, Zhihong Chen
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Clinical and Translational Medicine
Subjects:
Severe asthma
Oxidative stress
Phosphoinositide-3-kinase
Online Access:http://link.springer.com/article/10.1186/s40169-020-0262-5

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