| Summary: | No studies have yet investigated the influence of smoking on age at diagnosis of breast cancer. Therefore, the present study was carried out. This study consisted of 605 females with pathologically confirmed primary adenocarcinoma of the breast and 438 healthy females matched by age. Among our participants, 86 (14.2%) patients and 62 (14.1%) control subjects, respectively, were smokers. Based on a Cox regression model, evidence suggested that smoking status influenced the age at diagnosis of breast cancer (HR=0.78, 95% CI: 0.62-0.99, P=0.040). After stratification of the patients according to their menopausal status, the same results were obtained. The present study indicated that non-smokers have a lower age at diagnosis in comparison with patients who smoke.
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