Immunohistochemical Evaluation of Role of Serotonin in Pathogenesis of Psoriasis
Introduction: Psoriasis is a common skin disorder characterized by erythaematosquamous papules and plaques. It is known to be associated with stressful and depressive disorders. Serotonin is a neurotransmitter that plays a role in the pathogenesis of inflammatory skin disorders. Aim: To evaluat...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8719/22692_CE[Ra1]_F(GH)_PF1(PIAK)_PFA(NC)_PF2(P_PR).pdf |
| Summary: | Introduction: Psoriasis is a common skin disorder characterized
by erythaematosquamous papules and plaques. It is known to
be associated with stressful and depressive disorders. Serotonin
is a neurotransmitter that plays a role in the pathogenesis of
inflammatory skin disorders.
Aim: To evaluate the role of serotonin in pathogenesis of
psoriasis.
Materials and Methods: Using standard immunohistochemical
techniques, 24 biopsies from patients with chronic plaque
psoriasis were examined together with 12 biopsies from age
and gender-matched healthy subjects as a control group.
Results: Both the percentage of positive cells (p=0.018)
and H-score values (p=0.015) of serotonin expression were
significantly higher in psoriasis compared to normal skin. H
score of serotonin expression was significantly higher in cases
with totally absent Granular Cell Layer (GCL) as opposed to
those with thin/focally absent GCL (p=0.011), and in cases with
moderate/strong epidermal inflammation compared to cases
with mild inflammation (p=0.035). No significant correlation was
detected between H score of cases and age, disease duration
or Psoriasis Area and Severity Index (PASI) score.
Conclusion: Serotonin might play a role in development
of psoriasis through its role as a growth factor promoting
keratinocyte proliferation, and as mediator of inflammation
and stimulant of T cell activation. It recruits T cells to sites of
cutaneous inflammation and potentiate macrophage accessory
function for T cell activation. Its expression is not related to the
disease severity. Future large-scaled research on population of
different ethnicities including other disease variants is needed.
The use of serotonin receptor antagonists and serotonin
reuptake inhibitors may be evaluated on wide-based studies to
put the current observation into action. |
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| ISSN: | 2249-782X 0973-709X |