Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death

Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death

Disruption of neuronal networks in the Alzheimer-afflicted brain is increasingly recognized as a key correlate of cognitive and memory decline in Alzheimer patients. We hypothesized that functional synaptic disconnections within cortical columnar microcircuits by pathological β-amyloid accumulation,...

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Bibliographic Details
Main Authors: H. Lison, M.F.K. Happel, F. Schneider, K. Baldauf, S. Kerbstat, B. Seelbinder, J. Schneeberg, M. Zappe, J. Goldschmidt, E. Budinger, U.H. Schröder, F.W. Ohl, S. Schilling, H.-U. Demuth, H. Scheich, K.G. Reymann, R. Rönicke
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Neurobiology of Disease
Subjects:
β amyloid
Cortical column
Glutaminyl cyclase
Network disruption
Thallium uptake
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003276

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