Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at Pilot and Production Scale

Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at Pilot and Production Scale

Optimizing processing conditions to achieve a critical quality attribute (CQA) is an integral part of pharmaceutical quality by design (QbD). It identifies combinations of material and processing parameters ensuring that processing conditions achieve a targeted CQA. Optimum processing conditions are...

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Bibliographic Details
Main Authors: Raghu V. G. Peddapatla, Gerard Sheridan, Conor Slevin, Shrikant Swaminathan, Ivan Browning, Clare O’Reilly, Zelalem A. Worku, David Egan, Stephen Sheehan, Abina M. Crean
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
quality by design
tablet weight variability
powder flow
process optimization
process model
direct compression
Online Access:https://www.mdpi.com/1999-4923/13/7/1033

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https://www.mdpi.com/1999-4923/13/7/1033

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