In Vitro/Vivo Activity of Potential MCR-1 Inhibitor in Combination With Colistin Againsts mcr-1-Positive Klebsiella pneumonia

In Vitro/Vivo Activity of Potential MCR-1 Inhibitor in Combination With Colistin Againsts mcr-1-Positive Klebsiella pneumonia

Carbapenem resistance among strains of the nosocomial pathogen Klebsiella pneumoniae is increasing worldwide, causing serious clinical infections and higher mortality rates. Polymyxins are some of the few “last resort” options for treatment of carbapenem-resistant Enterobacteriaceae, including K. pn...

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Bibliographic Details
Main Authors: Yonglin Zhou, Tingting Wang, Yan Guo, Shui Liu, Jianfeng Wang, Yingbo Shen, Shusheng Tang, Yang Wang, Xuming Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
K. pneumonia
MCR-1 inhibitor
pterostilbene
colistin
combination therapy
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01615/full

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