Shikonin Inhibits Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts via lncRNA-NR024118

Shikonin Inhibits Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts via lncRNA-NR024118

Background. Shikonin is a major chemical component of zicao that possesses anti-inflammatory properties and the ability to mediate cellular and humoral immunity, especially in rheumatoid arthritis (RA). We investigated the impact of shikonin on inflammatory response in RA synovial fibroblasts using...

Full description

Bibliographic Details
Main Authors:	Ke-ya Yang, Dong-liang Chen
Format:	Article
Language:	English
Published:	Hindawi Limited 2015-01-01
Series:	Evidence-Based Complementary and Alternative Medicine
Online Access:	http://dx.doi.org/10.1155/2015/631737

Similar Items

Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
by: Jiahui Li, et al.
Published: (2021-09-01)

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation
by: Jenney, Anne P, et al.
Published: (2018)

Functional and transcriptional characterisation of synovial fibroblasts in early inflammatory arthritis and established rheumatoid arthritis
by: Juárez Pérez, María Jesús
Published: (2015)

Multiomics landscape of synovial fibroblasts in rheumatoid arthritis
by: Haruka Tsuchiya, et al.
Published: (2021-03-01)

Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients
by: Lifen Liao, et al.
Published: (2021-01-01)

Targeting Activated Synovial Fibroblasts in Rheumatoid Arthritis by Peficitinib
by: Magnus Diller, et al.
Published: (2019-03-01)

Characterization of the interaction between monocytes and synovial fibroblasts in rheumatoid arthritis
by: Chen, Victoria Tsui Lin
Published: (1996)

RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
by: Heruth Daniel P, et al.
Published: (2012-12-01)

Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
by: Manuel J. Del Rey, et al.
Published: (2019-11-01)

Suppression of Hyaluronan Synthesis Alleviates Inflammatory Responses in Murine Arthritis and in Human Rheumatoid Synovial Fibroblasts
by: 吉岡, 裕, et al.
Published: (2014)

Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts.
by: Tatsuo Watanabe, et al.
Published: (2016-01-01)

A Subpopulation of Synovial Fibroblasts Leads to Osteochondrogenesis in a Mouse Model of Chronic Inflammatory Rheumatoid Arthritis
by: Yoko Miura, et al.
Published: (2019-06-01)

Optimized “In Vitro” Culture Conditions for Human Rheumatoid Arthritis Synovial Fibroblasts
by: Claudia Casnici, et al.
Published: (2014-01-01)

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
by: Xiangyu Ge, et al.
Published: (2021-08-01)

Shikonin attenuates rheumatoid arthritis by targeting SOCS1/JAK/STAT signaling pathway of fibroblast like synoviocytes
by: Lianhua He, et al.
Published: (2021-10-01)

Integrative lncRNA–mRNA co‐expression network analysis identifies novel lncRNA E2F3‐IT1 for rheumatoid arthritis
by: Long‐Fei Wu, et al.
Published: (2021-02-01)

Circ_0000396 inhibits rheumatoid arthritis synovial fibroblast growth and inflammatory response via miR-203/HBP1 axis
by: Laifang Wang, et al.
Published: (2021-01-01)

Knockdown of YAP/TAZ Inhibits the Migration and Invasion of Fibroblast Synovial Cells in Rheumatoid Arthritis by Regulating Autophagy
by: Wei Zhou, et al.
Published: (2020-01-01)

New Insights From Single-Cell Sequencing Data: Synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis
by: Liyun Cheng, et al.
Published: (2021-07-01)

LncRNA PICSAR promotes cell proliferation, migration and invasion of fibroblast-like synoviocytes by sponging miRNA-4701-5p in rheumatoid arthritis
by: Xuan Bi, et al.
Published: (2019-12-01)

Osteochondrogenesis derived from synovial fibroblasts in inflammatory arthritis model
by: Yoko Miura, et al.
Published: (2020-05-01)

lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is Elevated in Rheumatoid Arthritis
by: Chin-An Yang, et al.
Published: (2018-09-01)

Importance of the novel organic cation transporter 1 for tyrosine kinase inhibition by saracatinib in rheumatoid arthritis synovial fibroblasts
by: Saliha Harrach, et al.
Published: (2017-04-01)

LncRNA NEAT1 Targets Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via the miR-410-3p/YY1 Axis
by: Yuejiao Wang, et al.
Published: (2020-08-01)

Reducing LncRNA-5657 expression inhibits the brain inflammatory reaction in septic rats
by: Yi-An Zhan, et al.
Published: (2021-01-01)

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders
by: Cheen Euong Ang, et al.
Published: (2019-01-01)

Hi-JAKi-ng Synovial Fibroblasts in Inflammatory Arthritis With JAK Inhibitors
by: Blaž Burja, et al.
Published: (2020-05-01)

Rheumatoid arthritis and osteoarthritis synovial fibroblasts express Fc[alpha]R (CD89) in vitro and in vivo : implications for rheumatoid arthritis
by: Wover, Roberta Michelle Antoinette
Published: (2013)

Rheumatoid arthritis and osteoarthritis synovial fibroblasts express Fc[alpha]R (CD89) in vitro and in vivo : implications for rheumatoid arthritis
by: Wover, Roberta Michelle Antoinette
Published: (2013)

CULTURES OF FIBROBLAST-LIKE SYNOVIAL CELLS FROM PATIENTS WITH RHEUMATOID ARTHRITIS: PROPERTIES AND OPPORTUNITIES
by: M. A. Schneider, et al.
Published: (2016-04-01)

Adipokines and Inflammation Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts and Endothelial Cells
by: Rebecca Hasseli, et al.
Published: (2020-06-01)

Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.
Published: (2005-10-01)

Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts
by: Emma R Dorris, et al.
Published: (2019-10-01)

Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis.
by: Vassilis Aidinis, et al.
Published: (2005-10-01)

Mechanisms of Bradykinin-induced Expression of Cyclooxygenase-2 in Human Synovial Fibroblasts of Rheumatoid Arthritis
by: Yu Wen Chen, et al.
Published: (2009)

LncRNA linc00152/NF‐κB feedback loop promotes fibroblast‐like synovial cells inflammation in rheumatoid arthritis via regulating miR‐103a/TAK1 axis and YY1 expression
by: Jian Zhang, et al.
Published: (2021-09-01)

Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis.
by: Hye Young Kim, et al.
Published: (2014-01-01)

Effect of JAK Inhibition on the Induction of Proinflammatory HLA–DR+CD90+ Rheumatoid Arthritis Synovial Fibroblasts by Interferon-γ
by: Andreeva, I., et al.
Published: (2022)

Lunasin Inhibits Cell Proliferation via Apoptosis and Reduces the Production of Proinflammatory Cytokines in Cultured Rheumatoid Arthritis Synovial Fibroblasts
by: Shaohui Jia, et al.
Published: (2015-01-01)

Role of lncRNA NR2F1-AS1 and lncRNA H19 Genes in Hepatocellular Carcinoma and Their Effects on Biological Function of Huh-7
by: Ji WC, et al.
Published: (2021-02-01)