Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient <i>mdx</i> Mice

Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient <i>mdx</i> Mice

Supporting mitochondrial function is one of the therapeutic strategies that improve the functioning of skeletal muscle in Duchenne muscular dystrophy (DMD). In this work, we studied the effect of a non-immunosuppressive inhibitor of mitochondrial permeability transition pore (MPTP) alisporivir (5 mg...

Full description

Bibliographic Details
Main Authors:	Mikhail V. Dubinin, Vlada S. Starinets, Eugeny Yu. Talanov, Irina B. Mikheeva, Natalia V. Belosludtseva, Dmitriy A. Serov, Kirill S. Tenkov, Evgeniya V. Belosludtseva, Konstantin N. Belosludtsev
Format:	Article
Language:	English
Published:	MDPI AG 2021-09-01
Series:	Biomedicines
Subjects:	Duchenne muscular dystrophy heart alisporivir mitochondria mitochondrial permeability transition
Online Access:	https://www.mdpi.com/2227-9059/9/9/1232

Similar Items

Alisporivir Improves Mitochondrial Function in Skeletal Muscle of <i>mdx</i> Mice but Suppresses Mitochondrial Dynamics and Biogenesis
by: Mikhail V. Dubinin, et al.
Published: (2021-09-01)

Effect of the MPT Pore Inhibitor Alisporivir on the Development of Mitochondrial Dysfunction in the Heart Tissue of Diabetic Mice
by: Natalia V. Belosludtseva, et al.
Published: (2021-08-01)

Alisporivir Treatment Alleviates Mitochondrial Dysfunction in the Skeletal Muscles of C57BL/6NCrl Mice with High-Fat Diet/Streptozotocin-Induced Diabetes Mellitus
by: Konstantin N. Belosludtsev, et al.
Published: (2021-09-01)

The Effect of Deflazacort Treatment on the Functioning of Skeletal Muscle Mitochondria in Duchenne Muscular Dystrophy
by: Mikhail V. Dubinin, et al.
Published: (2020-11-01)

Transport of Ca<sup>2+</sup> and Ca<sup>2+</sup>-Dependent Permeability Transition in the Liver and Heart Mitochondria of Rats with Different Tolerance to Acute Hypoxia
by: Konstantin N. Belosludtsev, et al.
Published: (2020-01-01)

Transport of Ca<sup>2+</sup> and Ca<sup>2+</sup>-Dependent Permeability Transition in Rat Liver Mitochondria under the Streptozotocin-Induced Type I Diabetes
by: Konstantin N. Belosludtsev, et al.
Published: (2019-08-01)

Peptide Nucleic Acid Promotes Systemic Dystrophin Expression and Functional Rescue in Dystrophin-deficient mdx Mice
by: Xianjun Gao, et al.
Published: (2015-01-01)

Study on skeletal muscle dystrophin and neuromuscular junction in adult and young mdx mice
by: Yu-ling ZHU, et al.
Published: (2015-05-01)

Metabolic remodeling agents show beneficial effects in the dystrophin<it>-</it>deficient <it>mdx</it> mouse model
by: Jahnke Vanessa E, et al.
Published: (2012-08-01)

Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice
by: Timothy M. Moore, et al.
Published: (2020-06-01)

iNOS is not responsible for RyR1 S-nitrosylation in mdx mice with truncated dystrophin
by: Ken’ichiro Nogami, et al.
Published: (2020-07-01)

Micro-dystrophin Gene Therapy Partially Enhances Exercise Capacity in Older Adult mdx Mice
by: Buel D. Rodgers, et al.
Published: (2020-06-01)

The Effect of S-15176 Difumarate Salt on Ultrastructure and Functions of Liver Mitochondria of C57BL/6 Mice with Streptozotocin/High-Fat Diet-Induced Type 2 Diabetes
by: Natalia V. Belosludtseva, et al.
Published: (2020-09-01)

Dystrophin Is Required for the Proper Timing in Retinal Histogenesis: A Thorough Investigation on the mdx Mouse Model of Duchenne Muscular Dystrophy
by: Irene Persiconi, et al.
Published: (2020-08-01)

Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse
by: S.L.L. Kueh, et al.
Published: (2011-09-01)

Concurrent Label-Free Mass Spectrometric Analysis of Dystrophin Isoform Dp427 and the Myofibrosis Marker Collagen in Crude Extracts from mdx-4cv Skeletal Muscles
by: Sandra Murphy, et al.
Published: (2015-09-01)

Effects of Mini-Dystrophin on Dystrophin-Deficient, Human Skeletal Muscle-Derived Cells
by: Jinhong Meng, et al.
Published: (2020-09-01)

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms
by: Brigitte Rosenwirth, et al.
Published: (2013-03-01)

Exon-specific monoclonal antibodies against dystrophin
by: Thanh, Le Thiet
Published: (1995)

Short-Term ONX-0914 Administration: Performance and Muscle Phenotype in <i>Mdx</i> Mice
by: Dongmin Kwak, et al.
Published: (2020-07-01)

Analysis of dystrophic mdx muscle following the implantation of normal dermal fibroblasts
by: Turner, Sally Ann
Published: (2001)

Long-Term Efficacy of Systemic Multiexon Skipping Targeting Dystrophin Exons 45–55 With a Cocktail of Vivo-Morpholinos in Mdx52 Mice
by: Yusuke Echigoya, et al.
Published: (2015-01-01)

Brain Dystrophin in Duchenne Dystrophy
by: J Gordon Millichap
Published: (1995-10-01)

Micro-dystrophin AAV Vectors Made by Transient Transfection and Herpesvirus System Are Equally Potent in Treating mdx Mouse Muscle Disease
by: Chady H. Hakim, et al.
Published: (2020-09-01)

Exercise-induced mechanisms of muscle adaptation in mdx mice
by: Lekan, Jaimy Marie
Published: (2004)

Lack of dystrophin functionally affects α3β2/β4-nicotinic acethylcholine receptors in sympathetic neurons of dystrophic mdx mice
by: Silvia Di Angelantonio, et al.
Published: (2011-02-01)

Effect of serotonin modulation on dystrophin-deficient zebrafish
by: Janelle M. Spinazzola, et al.
Published: (2020-08-01)

Resveratrol Promotes Hypertrophy in Wildtype Skeletal Muscle and Reduces Muscle Necrosis and Gene Expression of Inflammatory Markers in <i>Mdx</i> Mice
by: Keryn G. Woodman, et al.
Published: (2021-02-01)

Intellectual Ability in the Duchenne Muscular Dystrophy and Dystrophin Gene Mutation Location
by: Rasic Milic V., et al.
Published: (2014-12-01)

Diabetes Mellitus, Mitochondrial Dysfunction and Ca<sup>2+</sup>-Dependent Permeability Transition Pore
by: Konstantin N. Belosludtsev, et al.
Published: (2020-09-01)

Beneficial Role of Exercise in the Modulation of <i>mdx </i>Muscle Plastic Remodeling and Oxidative Stress
by: Monica Frinchi, et al.
Published: (2021-04-01)

Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model
by: Rachel T. Sullivan, et al.
Published: (2021-06-01)

Cell surface and gene expression regulation molecules in dystrophinopathy: mdx vs. Duchenne
by: RICARDO FADIC
Published: (2005-01-01)

Sphingolipids Modulate the Inflammatory and Functional Response in mdx Mice
by: Doering, Jonathan Adam
Published: (2015)

A comparison of the bone and growth phenotype of mdx, mdx:Cmah−/− and mdx:Utrn+/− murine models with the C57BL/10 wild-type mouse
by: Claire L. Wood, et al.
Published: (2020-02-01)

Effective restoration of dystrophin expression in iPSC Mdx-derived muscle progenitor cells using the CRISPR/Cas9 system and homology-directed repair technology
by: Yue Jin, et al.
Published: (2020-01-01)

Dystrophin Dp71 Subisoforms Localize to the Mitochondria of Human Cells
by: Emma Tabe Eko Niba, et al.
Published: (2021-09-01)

A Five-Repeat Micro-Dystrophin Gene Ameliorated Dystrophic Phenotype in the Severe DBA/2J-mdx Model of Duchenne Muscular Dystrophy
by: Chady H. Hakim, et al.
Published: (2017-09-01)

A real morfofisiologia do músculo diafragma após injeção local de células-tronco mesenquimais no modelo mdx
by: Thais Borges Lessa
Published: (2011)

A real morfofisiologia do músculo diafragma após injeção local de células-tronco mesenquimais no modelo mdx
by: Lessa, Thais Borges
Published: (2011)