The Possibilities of Acute Bronchopulmonary Diseases’ Monitoring Based on Analysis of Expired Breath Condensate

• Main Authors: Yu.V. Odynets, A.F. Ruchko, T.Yu. Cherednikova
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2013-05-01
• Series: Zdorovʹe Rebenka
• Subjects: pneumonia; surfactant; condensate; children
• Online Access: http://childshealth.zaslavsky.com.ua/article/view/89783

There were examined 74 children aged from 6 to 18 with complicated and lingering community-acquired pneumonia in order to increase the quality of medical and diagnostic services. Diagnosing and treatment of patients were conducted in according to «Child’s first aid proceedings within specialty "pediatric pulmonology"». Special study was conducted over the state of surfactant examination in indexes of lipids, their peroxidation and indexes of antioxidant defense in condensate of expired air in children with community-acquired pneumonia. It was reliably proved that serious and lingering forms of pneumonia in children resulted in severe surfactant damage which was associated with changes in indexes of lipids, their peroxidation and antioxidant defense in examined condensate of expired air. In the phase of acute pulmonary inflammation the indexes of total lipids, cholesterol, diene conjugate, malonic dialdehyde, catalase, superoxide dismutase statistically and significantly increased, the content of phospholipids were decreased. The level of mentioned changes corresponds to the degree of inflammation, availability of pulmonary complications (destructive and atelectatic), their extent and duration of illness. There was diagnosed the surfactant’s subclinical dysfunction in reconvalescence stage, which proves the necessity of control over bronchopulmonary conditions, in particular the surfactant at the stage of rehabilitation in the outpatient setting. These findings prompt for further examination of surfactant — protection therapy and its use on prediction of complicating and lingering pneumonia in children.