Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection

Characterization of fragment sizes, copy number aberrations and 4‐mer end motifs in cell‐free DNA of hepatocellular carcinoma for enhanced liquid biopsy‐based cancer detection

Circulating cell‐free DNA (cfDNA) fragmentomics, which encompasses the measurement of cfDNA length and short nucleotide motifs at the ends of cfDNA molecules, is an emerging field for cancer diagnosis. The utilization of cfDNA fragmentomics for the diagnosis of patients with hepatocellular carcinoma...

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Bibliographic Details
Main Authors: Chao Jin, Xiaonan Liu, Wenyuan Zheng, Liping Su, Yang Liu, Xu Guo, Xiaoming Gu, Hongping Li, Bo Xu, Gang Wang, Jiyan Yu, Qiong Zhang, Dengke Bao, Shaogui Wan, Fei Xu, Xiaohuan Lai, Jiayun Liu, Jinliang Xing
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Molecular Oncology
Subjects:
circulating cell‐free DNA
copy number variation
end motifs
fragment sizes
hepatocellular carcinoma
tumor fraction
Online Access:https://doi.org/10.1002/1878-0261.13041

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