Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model

Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model

Lactobacillus reuteri L3 and Lactobacillus reuteri L10 were selected to investigate whether different strains from the same probiotic species, but isolated from different phenotype mice (normal or obese mice), modulated metabolic phenotypes such as obesity. The results indicate that L. reuteri L3 (b...

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Main Authors: Yi Qiao, Jin Sun, Shufang Xia, Liting Li, Ya Li, Panpan Wang, Yonghui Shi, Guowei Le
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Journal of Functional Foods
Subjects:
Fat storage
Inflammatory
Lactobacillus reuteri
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615000754
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spelling doaj-90b455b57eaa4a4485707a276e2948f72021-04-29T04:43:54ZengElsevierJournal of Functional Foods1756-46462015-04-0114424434Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice modelYi Qiao0Jin Sun1Shufang Xia2Liting Li3Ya Li4Panpan Wang5Yonghui Shi6Guowei Le7Department of Public Health, Jining Medical University, Jining, China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; Food Nutrition and Functional Factors Research Centre, School of Food Science and Technology, Jiangnan University, Wuxi, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; Food Nutrition and Functional Factors Research Centre, School of Food Science and Technology, Jiangnan University, Wuxi, China; Corresponding author. School of Food Science and Technology, Jiangnan University, Wuxi, China. Tel.: +86 510 85829100; fax: +86 510 85817789.Lactobacillus reuteri L3 and Lactobacillus reuteri L10 were selected to investigate whether different strains from the same probiotic species, but isolated from different phenotype mice (normal or obese mice), modulated metabolic phenotypes such as obesity. The results indicate that L. reuteri L3 (but not L. reuteri L10) significantly decreased body weight, glucose, insulin, lipopolysaccharide (LPS), and pro-inflammatory cytokine levels and increased energy expenditure (measured by heat production and ambulatory activity) compared with the high-fat diet group. Moreover, the mRNA levels of Ppar-γ, Acc1, and Fas in adipocytes were significantly suppressed, and the mRNA level of Cyp7a1 in liver was promoted by L. reuteri L3, not by L. reuteri L10. These activities may contribute to significant anti-obesity effects of L. reuteri L3. In addition, bacterial strains of the same species showed different effects on inflammatory and obesity, illustrating the complexity of host-bacterial cross-talk and the importance of investigating specific bacterial strains.http://www.sciencedirect.com/science/article/pii/S1756464615000754Fat storageInflammatoryLactobacillus reuteriObesity
collection DOAJ
language English
format Article
sources DOAJ
author Yi Qiao
Jin Sun
Shufang Xia
Liting Li
Ya Li
Panpan Wang
Yonghui Shi
Guowei Le
spellingShingle Yi Qiao
Jin Sun
Shufang Xia
Liting Li
Ya Li
Panpan Wang
Yonghui Shi
Guowei Le
Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model
Journal of Functional Foods
Fat storage
Inflammatory
Lactobacillus reuteri
Obesity
author_facet Yi Qiao
Jin Sun
Shufang Xia
Liting Li
Ya Li
Panpan Wang
Yonghui Shi
Guowei Le
author_sort Yi Qiao
title Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model
title_short Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model
title_full Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model
title_fullStr Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model
title_full_unstemmed Effects of different Lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model
title_sort effects of different lactobacillus reuteri on inflammatory and fat storage in high-fat diet-induced obesity mice model
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2015-04-01
description Lactobacillus reuteri L3 and Lactobacillus reuteri L10 were selected to investigate whether different strains from the same probiotic species, but isolated from different phenotype mice (normal or obese mice), modulated metabolic phenotypes such as obesity. The results indicate that L. reuteri L3 (but not L. reuteri L10) significantly decreased body weight, glucose, insulin, lipopolysaccharide (LPS), and pro-inflammatory cytokine levels and increased energy expenditure (measured by heat production and ambulatory activity) compared with the high-fat diet group. Moreover, the mRNA levels of Ppar-γ, Acc1, and Fas in adipocytes were significantly suppressed, and the mRNA level of Cyp7a1 in liver was promoted by L. reuteri L3, not by L. reuteri L10. These activities may contribute to significant anti-obesity effects of L. reuteri L3. In addition, bacterial strains of the same species showed different effects on inflammatory and obesity, illustrating the complexity of host-bacterial cross-talk and the importance of investigating specific bacterial strains.
topic Fat storage
Inflammatory
Lactobacillus reuteri
Obesity
url http://www.sciencedirect.com/science/article/pii/S1756464615000754
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