The APC/C Ubiquitin Ligase: from Cell Biology to Tumorigenesis

The APC/C Ubiquitin Ligase: from Cell Biology to Tumorigenesis

The ubiquitin proteasome system (UPS) is required for normal cell proliferation, vertebrate development, and cancer cell transformation. The UPS consists of multiple proteins that work in concert to target a protein for degradation via the 26S proteasome. Chains of an 8.5 kDa protein called ubiquiti...

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Bibliographic Details
Main Authors: Clara ePenas, Vimal eRamachandran, Nagi George Ayad
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-01-01
Series:Frontiers in Oncology
Subjects:
Cell Cycle
Ubiquitin
Cancer
differentiation
cancer therapy
ubiquitin ligase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2011.00060/full

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