Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice

Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice

The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic benzodiazepine, were examined in mice. In the elevated plus-maze test of anxiety, 0.3-1 mg/kg diazepam ip (F(3,53) = 3.78; P<0.05) and 1-10 mg/kg PTMB ip increased (F(5,98) =...

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Bibliographic Details
Main Authors: M.A. Rubin, C.A. Albach, D.B. Berlese, H.G. Bonacorso, S.R.T. Bittencourt, C.M.T. Queiroz, A.E. Maixner, C.F. Mello
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2000-09-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
anxiolytic
1,5-benzodiazepine
diazepam
elevated plus-maze
holeboard
picrotoxin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900013

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