Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

Background: Accumulating evidence suggests inhibiting neuroinflammation as a potential target in therapeutic or preventive strategies for Alzheimer's disease (AD). MAPK-activated protein kinase II (MK2), downstream kinase of p38 mitogen activated protein kinase (MAPK) p38 MAPK, was unveiled as...

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Bibliographic Details
Main Authors: JinHong Jiang, Zhe Wang, XueYa Liang, YaoYan Nie, Xin Chang, HongXiang Xue, Shu Li, Chang Min
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
MMI-0100
neuroinflammation
MAPK-activated protein kinase II (MK2)
intranasal
near-infrared fluorescent
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02707/full

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