Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life

Repeat-induced point mutation in Neurospora crassa causes the highest known mutation rate and mutational burden of any cellular life

Abstract Background Repeat-induced point (RIP) mutation in Neurospora crassa degrades transposable elements by targeting repeats with C→T mutations. Whether RIP affects core genomic sequence in important ways is unknown. Results By parent-offspring whole genome sequencing, we estimate a mutation rat...

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Bibliographic Details
Main Authors: Long Wang, Yingying Sun, Xiaoguang Sun, Luyao Yu, Lan Xue, Zhen He, Ju Huang, Dacheng Tian, Laurence D. Hurst, Sihai Yang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Genome Biology
Subjects:
Neurospora crassa
Repeat-induced point (RIP) mutation
Mutational burden
Resequencing
Online Access:http://link.springer.com/article/10.1186/s13059-020-02060-w

Internet

http://link.springer.com/article/10.1186/s13059-020-02060-w

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