Antioxidants Reduce Muscular Dystrophy in the <i>dy<sup>2J</sup>/dy<sup>2J</sup></i> Mouse Model of Laminin α2 Chain-Deficient Muscular Dystrophy

Antioxidants Reduce Muscular Dystrophy in the <i>dy<sup>2J</sup>/dy<sup>2J</sup></i> Mouse Model of Laminin α2 Chain-Deficient Muscular Dystrophy

Congenital muscular dystrophy with laminin &#945;2 chain-deficiency (LAMA2-CMD) is a severe neuromuscular disorder without a cure. Using transcriptome and proteome profiling as well as functional assays, we previously demonstrated significant metabolic impairment in skeletal muscle from LAMA2-CM...

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Bibliographic Details
Main Authors: Vahid M. Harandi, Bernardo Moreira Soares Oliveira, Valérie Allamand, Ariana Friberg, Cibely C. Fontes-Oliveira, Madeleine Durbeej
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Antioxidants
Subjects:
laminin
reactive oxygen species
congenital muscular dystrophy
therapy
Online Access:https://www.mdpi.com/2076-3921/9/3/244

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