The research of profile of specific autoantibodies at the different forms of EBV-infection

• Main Author: Татьяна Ивановна Лядова
• Format: Article
• Language: English
• Published: PC Technology Center 2016-08-01
• Series: ScienceRise: Medical Science
• Online Access: http://journals.uran.ua/sr_med/article/view/76557

There were presented the data of dynamics of specific autoimmune markers levels at acute and chronic forms of Epstein barr viral infection in adults. The received results testify to activation of autoimmune processes, especially in patients with chronic clinical course of disease. Aim of research. To assess the dynamics of specific autoimmune markers in adult patients with the different variants of EB viral infection. Methods. The study of levels of specific antibodies to phospholipids (IgM and IgG), antibodies to the native DNA IgG (ADNA 2) and antibodies IgG to microsomes of liver and kidneys (anti-LKM-1) by IEA in the dynamics of disease included 2 groups of patients (n=84), among them 44 men (52,4 %) and 40 women (47,6 %). The group of patients with acute form of EB viral infection included 48 patients (57,1 %), with chronic form – 36 patients (42,9 %). Antibodies concentration in blood serum was determined by the solid-phase immune-enzyme analysis in the dynamics of disease: at admission of patients (I period) and in the period of recovery (14-18-th day of disease) – I period on the background of etiotropic, pathogenetic and symptomatic therapy. Statistical procession of the results was carried out using the program Statistika 6.0 for Windows (Stat Soft Inc, USA). Results. During the research it was established the increase of content of specific autoimmune parameters comparing with ones of the control group. At both acute and chronic forms the reliable increase of content of antibodies to ADNA 2 (7,96±1,4 IU/ml) and (8,98±1,1 IU/ml) was revealed comparing with parameters of the control group (5,4±1,4 IU/ml), (p<0,05). Analogous tendency was observed as to the levels of phospholipid antibodies: (4,62±1,5 IU/ml) and (4,95±1,1 IU/ml) comparing with parameters of the control group (3,6±1,8 IU/ml) and antibodies to macrosomes of liver and kidneys (anti-LKM-1) (8,64±1,5 IU/ml) and (9,36±1,11IU/ml), comparing with parameters of the control group (6,6±1,1 IU/ml), (p<0,05). At the repeated examination in II period the tendency to decrease of the studied parameters levels was observed comparing with I one, but in patients with chronic EB viral infection the level of antiphospholipid antibodies reliably exceeded the parameters of the control group of patients (4,95±1,12 IU/ml) comparing with (3,6±1,8 IU/ml), (p<0,05). Conclusions. In patients with the different forms of EB viral infection the increase of content of specific antibodies to phospholipids (IgM and IgG), antibodies to the native DNA IgG (ADNA 2) and antibodies IgG to microsomes of liver and kidneys (anti-LKM-1)was observed and it was mostly expressed at the chronic clinical course of disease