Linezolid Exerts Greater Bacterial Clearance but No Modification of Host Lung Gene Expression Profiling: A Mouse MRSA Pneumonia Model.

Linezolid Exerts Greater Bacterial Clearance but No Modification of Host Lung Gene Expression Profiling: A Mouse MRSA Pneumonia Model.

BACKGROUND:Linezolid (LZD) is beneficial to patients with MRSA pneumonia, but whether and how LZD influences global host lung immune responses at the mRNA level during MRSA-mediated pneumonia is still unknown. METHODS:A lethal mouse model of MRSA pneumonia mediated by USA300 was employed to study th...

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Bibliographic Details
Main Authors: Jiwang Chen, Gang Feng, Yang Song, Juliane B Wardenburg, Simon Lin, Ichiro Inoshima, Michael Otto, Richard G Wunderink
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3694879?pdf=render

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