miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer

• Main Authors: Wang J, Wang L, Zhang C
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-08-01
• Series: OncoTargets and Therapy
• Subjects: non-small cell lung cancer; mir-765; prognosis; progression
• Online Access: https://www.dovepress.com/mir-765-acts-as-a-tumor-promoter-and-indicates-poor-prognosis-in-non-s-peer-reviewed-fulltext-article-OTT

Jiying Wang,1,* Li Wang,1,* Congjun Zhang2 1Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Congjun Zhang Email [e-mail]: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related death worldwide with poor prognosis. Accumulating evidence indicates that miR-765 is an important regulator in the progression and prognosis of various cancers. In this study, the function in the progression and prognosis of NSCLC was investigated.Patients and Methods: The expression of miR-765 in NSCLC was analyzed by qRT-PCR. The effect of miR-765 on cell proliferation, migration, and invasion of NSCLC was evaluated by CCK8 and Transwell assay. Kaplan–Meier analysis and Cox regression analysis were employed to assess the prognostic value of miR-765.Results: The results demonstrated the significant upregulation of miR-765 in NSCLC tissues and cell lines relative to normal tissues and cells. High miR-765 expression was significantly correlated with the TNM stage of patients. Patients with high miR-765 expression showed a poorer prognosis than that of patients with low miR-765 expression. Cox analysis indicated that miR-765 could be considered as an independent prognostic factor for NSCLC. Additionally, the upregulation of miR-765 was revealed to promote NSCLC cell proliferation, migration, and invasion by targeting BMP6.Conclusion: The overexpression of miR-765 in NSCLC was associated with TNM stage and poor prognosis of patients. miR-765 served as a tumor promoter of NSCLC by regulating BMP6. These findings provide a potential biomarker and therapeutic target for the prognosis and treatment of NSCLC.Keywords: non-small cell lung cancer, miR-765, prognosis, progression