CD4/CD8 Antibodies Reduce Histopathological Damage in Salivary Glands of Spontaneously Diabetic Mice

CD4/CD8 Antibodies Reduce Histopathological Damage in Salivary Glands of Spontaneously Diabetic Mice

Background and aims: Diabetes affects the metabolism promoting damage in different tissues, including salivary glands. Current treatments, such as insulin, are ineffective to recovery of these tissues. In this aspect, the immunotherapy has been tested, but it can be inefficient as an agent for the c...

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Bibliographic Details
Main Authors: Netto Raphael Oliveira Ramos Franco, Moura Eliézer Guimarães, Col Luan Oenning, Barros Magda Jaciara, Netto Juliana de Almeida Rodrigues Franco, Cajazeiro Débora Chaves, Fernandes Victor Augusto Ramos, Farias Danielle Aranha, Caldeira Eduardo José
Format: Article
Language:English
Published: Sciendo 2019-06-01
Series:Romanian Journal of Diabetes Nutrition and Metabolic Diseases
Subjects:
anti cd4 and cd8
immunotherapy
salivary glands
diabetes mellitus
Online Access:https://doi.org/10.2478/rjdnmd-2019-0016
Description
Summary:Background and aims: Diabetes affects the metabolism promoting damage in different tissues, including salivary glands. Current treatments, such as insulin, are ineffective to recovery of these tissues. In this aspect, the immunotherapy has been tested, but it can be inefficient as an agent for the control of damage caused by diabetes. The aim of this study to evaluate the association in anti-CD4 and anti-CD8 monoclonal antibody in the recovery of salivary glands of diabetic NOD mice.
ISSN:2284-6417

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