Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia
The natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia. We first reported the clonal evolution in a long-term follow-up patient with hypere...
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2019-01-01
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| Series: | Leukemia Research Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048918300736 |
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doaj-908af35940b045aa89da52cf925e7e662020-11-25T02:15:02ZengElsevierLeukemia Research Reports2213-04892019-01-01112426Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophiliaMeiyu Chen0Jie Liu1Wei Qin2Qian Wang3Ri Zhang4Hongying Chao5Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, ChinaDepartment of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, ChinaDepartment of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, ChinaDepartment of Hematology, The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, Jiangsu 215006, ChinaDepartment of Hematology, The First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, Jiangsu 215006, ChinaDepartment of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, China; Corresponding author.The natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia. We first reported the clonal evolution in a long-term follow-up patient with hypereosinophilia. This case initially presented with chronic eosinophilic leukemia, not otherwise specified (CEL-NOS), successively transformed to myelodysplastic syndromes (MDS) and acute myeloid leukemia(s-AML). We identified three mutations at CEL-NOS phase, five and seven mutations at MDS and s-AML stages, respectively. Our data illustrate the clonal dynamic process associated with disease evolution from CEL-NOS to s-AML. Keywords: Hypereosinophilia, Clonal evolution, Next generation sequencinghttp://www.sciencedirect.com/science/article/pii/S2213048918300736 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Meiyu Chen Jie Liu Wei Qin Qian Wang Ri Zhang Hongying Chao |
| spellingShingle |
Meiyu Chen Jie Liu Wei Qin Qian Wang Ri Zhang Hongying Chao Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia Leukemia Research Reports |
| author_facet |
Meiyu Chen Jie Liu Wei Qin Qian Wang Ri Zhang Hongying Chao |
| author_sort |
Meiyu Chen |
| title |
Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia |
| title_short |
Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia |
| title_full |
Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia |
| title_fullStr |
Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia |
| title_full_unstemmed |
Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia |
| title_sort |
clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia |
| publisher |
Elsevier |
| series |
Leukemia Research Reports |
| issn |
2213-0489 |
| publishDate |
2019-01-01 |
| description |
The natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia. We first reported the clonal evolution in a long-term follow-up patient with hypereosinophilia. This case initially presented with chronic eosinophilic leukemia, not otherwise specified (CEL-NOS), successively transformed to myelodysplastic syndromes (MDS) and acute myeloid leukemia(s-AML). We identified three mutations at CEL-NOS phase, five and seven mutations at MDS and s-AML stages, respectively. Our data illustrate the clonal dynamic process associated with disease evolution from CEL-NOS to s-AML. Keywords: Hypereosinophilia, Clonal evolution, Next generation sequencing |
| url |
http://www.sciencedirect.com/science/article/pii/S2213048918300736 |
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