CoCl2 simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis

CoCl2 simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis

Abstract Background/aims Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies. HIF-1α acts as an important transcriptional regulator directly or indirectly associated with genes involved in...

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Bibliographic Details
Main Authors: Nishant Kumar Rana, Priya Singh, Biplob Koch
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Biological Research
Subjects:
Hypoxia
Apoptosis
CoCl2
HIF-1α
VEGF
p53
Online Access:http://link.springer.com/article/10.1186/s40659-019-0221-z

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