Molecular Modeling Study for the Design of Novel Peroxisome Proliferator-Activated Receptor Gamma Agonists using 3D-QSAR and Molecular Docking

Molecular Modeling Study for the Design of Novel Peroxisome Proliferator-Activated Receptor Gamma Agonists using 3D-QSAR and Molecular Docking

Type 2 diabetes is becoming a global pandemic disease. As an important target for the generation and development of diabetes mellitus, peroxisome proliferator-activated receptor γ (PPARγ) has been widely studied. PPARγ agonists have been designed as potential anti-diabetic agents. The advanced devel...

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Bibliographic Details
Main Authors: Yaning Jian, Yuyu He, Jingjing Yang, Wei Han, Xifeng Zhai, Ye Zhao, Yang Li
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
PPARγ
N-benzylbenzamide derivatives
3D-QSAR
CoMFA
CoMSIA
molecular docking
Online Access:http://www.mdpi.com/1422-0067/19/2/630

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http://www.mdpi.com/1422-0067/19/2/630

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