A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro

A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro

Remarkable advances in three-dimensional (3D) cell cultures and organ-on-a-chip technologies have opened the door to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. The challenges regarding oxygen delivery, throughput, assay multiplexing, and experimental co...

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Bibliographic Details
Main Authors: James T. Shoemaker, Wanrui Zhang, Selin I. Atlas, Richard A. Bryan, S. Walker Inman, Jelena Vukasinovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
3D cell culture
organ-on-a-chip
liver model
CYP450
drug metabolism
cell metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.568777/full

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