• Main Authors: Rosangela Silva Rigo, Cristiano Marcelo Espínola Carvalho, Michael Robin Honer, Gisele Braziliano de Andrade, Iandara Shetter Silva, Leonardo Rigo, Helen Rezende Figueiredo, Wanessa Teixeira Gomes Barreto
• Format: Article
• Language: English
• Published: Universidade de São Paulo 2013-04-01
• Series: Revista do Instituto de Medicina Tropical de São Paulo
• Subjects: Renal histopathology; Visceral leishmaniasis; Dogs
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652013000200113

<p id="para1">Visceral leishmaniasis affects various organs including the kidneys; which can lead to renal failure and death. In order to verify this renal involvement, material was evaluated from 100 dogs naturally infected and with serological diagnosis of canine visceral leishmaniasis (CVL). Inflammatory changes were present in 25.3% of the tubules, in 67.0% of interstitium and in 52.0% of glomeruli. There was no significant difference (p > 0.05) between the presence of glomerulonephritis in symptomatic and oligosymptomatic dogs. The membranous and membranoproliferative glomerulonephritis were the most frequent, both with 18.0% frequency, followed by focal segmental glomerulosclerosis with 14.0%. Changes such as cylindruria, tubular and fibrosis hypertrophy, periglomerular inflammatory infiltrate, and multifocal and diffuse peritubular inflammatory infiltrate were observed. The findings are consistent with those of other authors indicating that renal involvement is common in CVL and the standards of membranous and membranoploriferative glomerulonephritis, as well as the tubulointerstitial involvement, are frequent.<br><p id="para2">A leishmaniose visceral acomete v&#225;rios &#243;rg&#227;os entre eles os rins; o que pode levar a insufici&#234;ncia renal e a morte. Com o objetivo de verificar este acometimento renal foram avaliados materiais de 100 c&#227;es naturalmente infectados e com diagn&#243;sticos sorol&#243;gicos de leishmaniose visceral canina - LVC. As altera&#231;&#245;es inflamat&#243;rias estavam presentes em 25,3% dos t&#250;bulos, em 67,0% do interst&#237;cio e em 52,0% dos glom&#233;rulos. N&#227;o houve diferen&#231;a significativa (p > 0,05) entre a presen&#231;a de glomerulonefrite em c&#227;es sintom&#225;ticos e oligossintom&#225;ticos. As glomerulonefrites membranosa e membrano proliferativa foram as mais freq&#252;entes, ambas com 18,0% de freq&#252;&#234;ncia seguidas da glomeruloesclerose segmentar e focal com 14,0%. Foram observadas altera&#231;&#245;es como cilindr&#250;ria, hipertrofia tubular e fibrose e infiltrados inflamat&#243;rios periglomerulares e peritubulares multifocais e difusos. Os achados concordam com os de outros autores indicando que o acometimento renal &#233; comum na LVC e que os padr&#245;es de glomerulonefrites membranoploriferativa e membranosa; assim como o acometimento tubulointersticial s&#227;o freq&#252;entes.