Structural features of the αβTCR mechanotransduction apparatus that promote pMHC discrimination

Structural features of the αβTCR mechanotransduction apparatus that promote pMHC discrimination

The αβTCR was recently revealed to function as a mechanoreceptor. That is, it leverages mechanical energy generated during immune surveillance and at the immunological synapse to drive biochemical signaling following ligation by a specific foreign peptide-MHC complex (pMHC). Here we review the struc...

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Bibliographic Details
Main Authors: Kristine N Brazin, Robert J Mallis, Dibyendu Kumar Das, Yinnian eFeng, Wonmuk eHwang, Jia-huai eWang, Gerhard eWagner, Matthew J Lang, Ellis L Reinherz
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
CD3
antigen recognition
mechanosensor
thymic development
Catch bond
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00441/full

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