Cortical thickness is differently associated with ALDH2 rs671 polymorphism according to level of amyloid deposition

Cortical thickness is differently associated with ALDH2 rs671 polymorphism according to level of amyloid deposition

Abstract Accumulating evidence indicates that amyloid-beta (Aβ) deposition and biogenic aldehyde accumulation contribute to the pathogenesis of neurodegenerative diseases. Human aldehyde dehydrogenase 2 (ALDH2) metabolizes biogenic aldehydes produced in the brain to prevent damage. However, r671G>...

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Main Authors: Yong Hyuk Cho, Heirim Lee, Na-Rae Kim, Jin Wook Choi, Hyun Woong Roh, Jae Ho Ha, Chang Hyung Hong, Sang Won Seo, Seong Hye Choi, Eun-Joo Kim, Byeong C. Kim, Seong Yoon Kim, Jaeyoun Cheong, Bumhee Park, Sang Joon Son
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-98834-8

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