Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF-κB/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells

Camptothecin Inhibits Neddylation to Activate the Protective Autophagy Through NF-κB/AMPK/mTOR/ULK1 Axis in Human Esophageal Cancer Cells

The neddylation pathway is overactivated in esophageal cancer. Our previous studies indicated that inactivation of neddylation by the NAE inhibitor induced apoptosis and autophagy in cancer cells. Camptothecin (CPT), a well-known anticancer agent, could induce apoptosis and autophagy in cancer cells...

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Bibliographic Details
Main Authors: Yongqing Heng, Yupei Liang, Junqian Zhang, Lihui Li, Wenjuan Zhang, Yanyu Jiang, Shiwen Wang, Lijun Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
camptothecin
neddylation
p-IκBα
NF-κB/AMPK/mTOR/ULK1
autophagy
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.671180/full

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