Paroxysmal extreme pain disorder M1627K mutation in human Na<sub>v</sub>1.7 renders DRG neurons hyperexcitable

Paroxysmal extreme pain disorder M1627K mutation in human Na<sub>v</sub>1.7 renders DRG neurons hyperexcitable

<p>Abstract</p> <p>Background</p> <p>Paroxysmal extreme pain disorder (PEPD) is an autosomal dominant painful neuropathy with many, but not all, cases linked to gain-of-function mutations in <it>SCN9A </it>which encodes voltage-gated sodium channel Na<sub...

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Bibliographic Details
Main Authors: Tyrrell Lynda, Jarecki Brian W, Estacion Mark, Dib-Hajj Sulayman D, Fischer Tanya Z, Lawden Mark, Cummins Theodore R, Waxman Stephen G
Format: Article
Language:English
Published: SAGE Publishing 2008-09-01
Series:Molecular Pain
Online Access:http://www.molecularpain.com/content/4/1/37

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