Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

Hepatitis C Virus Deletion Mutants Are Found in Individuals Chronically Infected with Genotype 1 Hepatitis C Virus in Association with Age, High Viral Load and Liver Inflammatory Activity.

Hepatitis C virus (HCV) variants characterized by genomic deletions in the structural protein region have been sporadically detected in liver and serum of hepatitis C patients. These defective genomes are capable of autonomous RNA replication and are packaged into infectious viral particles in cells...

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Main Authors: Cristina Cheroni, Lorena Donnici, Alessio Aghemo, Francesca Balistreri, Annalisa Bianco, Valeria Zanoni, Massimiliano Pagani, Roberta Soffredini, Roberta D'Ambrosio, Maria Grazia Rumi, Massimo Colombo, Sergio Abrignani, Petra Neddermann, Raffaele De Francesco
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4583497?pdf=render

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