Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware!
The excessive chase for beauty standards and the rise of muscle dysmorphia have ultimately led to an increase in androgenic–anabolic steroids (AAS) and intramuscular injections of vitamins A, D and E (ADE) abuse, which is associated with several adverse effects and has become a public health issue....
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Elsevier
2020-01-01
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| Series: | Nefrología (English Edition) |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2013251420300237 |
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doaj-9039be105b184325b1958449cd2a28ea2020-11-25T02:10:33ZengElsevierNefrología (English Edition)2013-25142020-01-014012631Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware!Sérgio Luiz Arruda Parente Filho0Pedro Eduardo Andrade de Carvalho Gomes1Guilherme Aguiar Forte2Laio Ladislau Lopes Lima3Geraldo Bezerra da Silva Júnior4Gdayllon Cavalcante Meneses5Alice Maria Costa Martins6Elizabeth De Francesco Daher7Medical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, BrazilMedical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, BrazilMedical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, BrazilMedical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, BrazilPublic Health Post-Graduation Program, School of Medicine, Health Sciences Center, University of Fortaleza, Ceará, BrazilDepartment of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, BrazilDepartment of Clinical and Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, BrazilMedical Sciences Post-Graduation Program, Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; Corresponding author.The excessive chase for beauty standards and the rise of muscle dysmorphia have ultimately led to an increase in androgenic–anabolic steroids (AAS) and intramuscular injections of vitamins A, D and E (ADE) abuse, which is associated with several adverse effects and has become a public health issue. This review of literature discusses kidney injury associated with the use of AAS and ADE, highlighting the mechanisms of acute and chronic renal lesion, such as direct renal toxicity, glomerular hyperfiltration and hypercalcemia. Future perspectives regarding evaluation and early diagnosis of kidney injury in these patients are also discussed. Resumen: La búsqueda excesiva de los estándares estéticos y el aumento de casos de dismorfia muscular han llevado a un aumento excesivo del consumo de esteroides anabólicos androgénicos (AAS, por sus siglas en inglés) e inyecciones intramusculares de vitaminas A, D y E (ADE), que se asocian con varios efectos adversos y se convierte en un problema de salud pública. Esta revisión de literatura analiza la lesión renal asociada con el uso de AAS y vitaminas ADE, destacando los mecanismos de la lesión renal aguda y crónica, como la toxicidad renal directa, la hiperfiltración glomerular y la hipercalcemia. También se discuten las perspectivas futuras con respecto a la evaluación y el diagnóstico temprano de lesión renal en estos pacientes. Keywords: Acute kidney injury, Androgenic–anabolic steroids, Chronic kidney disease, Hypercalcemia, Vitamin D, Vitamin supplements, Palabras clave: Lesión renal aguda, Esteroides androgénicos-anabólicos, Enfermedad renal crónica, Hipercalcemia, Vitamina D, Suplementos vitamínicoshttp://www.sciencedirect.com/science/article/pii/S2013251420300237 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sérgio Luiz Arruda Parente Filho Pedro Eduardo Andrade de Carvalho Gomes Guilherme Aguiar Forte Laio Ladislau Lopes Lima Geraldo Bezerra da Silva Júnior Gdayllon Cavalcante Meneses Alice Maria Costa Martins Elizabeth De Francesco Daher |
| spellingShingle |
Sérgio Luiz Arruda Parente Filho Pedro Eduardo Andrade de Carvalho Gomes Guilherme Aguiar Forte Laio Ladislau Lopes Lima Geraldo Bezerra da Silva Júnior Gdayllon Cavalcante Meneses Alice Maria Costa Martins Elizabeth De Francesco Daher Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware! Nefrología (English Edition) |
| author_facet |
Sérgio Luiz Arruda Parente Filho Pedro Eduardo Andrade de Carvalho Gomes Guilherme Aguiar Forte Laio Ladislau Lopes Lima Geraldo Bezerra da Silva Júnior Gdayllon Cavalcante Meneses Alice Maria Costa Martins Elizabeth De Francesco Daher |
| author_sort |
Sérgio Luiz Arruda Parente Filho |
| title |
Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware! |
| title_short |
Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware! |
| title_full |
Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware! |
| title_fullStr |
Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware! |
| title_full_unstemmed |
Kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: Be aware! |
| title_sort |
kidney disease associated with androgenic–anabolic steroids and vitamin supplements abuse: be aware! |
| publisher |
Elsevier |
| series |
Nefrología (English Edition) |
| issn |
2013-2514 |
| publishDate |
2020-01-01 |
| description |
The excessive chase for beauty standards and the rise of muscle dysmorphia have ultimately led to an increase in androgenic–anabolic steroids (AAS) and intramuscular injections of vitamins A, D and E (ADE) abuse, which is associated with several adverse effects and has become a public health issue. This review of literature discusses kidney injury associated with the use of AAS and ADE, highlighting the mechanisms of acute and chronic renal lesion, such as direct renal toxicity, glomerular hyperfiltration and hypercalcemia. Future perspectives regarding evaluation and early diagnosis of kidney injury in these patients are also discussed. Resumen: La búsqueda excesiva de los estándares estéticos y el aumento de casos de dismorfia muscular han llevado a un aumento excesivo del consumo de esteroides anabólicos androgénicos (AAS, por sus siglas en inglés) e inyecciones intramusculares de vitaminas A, D y E (ADE), que se asocian con varios efectos adversos y se convierte en un problema de salud pública. Esta revisión de literatura analiza la lesión renal asociada con el uso de AAS y vitaminas ADE, destacando los mecanismos de la lesión renal aguda y crónica, como la toxicidad renal directa, la hiperfiltración glomerular y la hipercalcemia. También se discuten las perspectivas futuras con respecto a la evaluación y el diagnóstico temprano de lesión renal en estos pacientes. Keywords: Acute kidney injury, Androgenic–anabolic steroids, Chronic kidney disease, Hypercalcemia, Vitamin D, Vitamin supplements, Palabras clave: Lesión renal aguda, Esteroides androgénicos-anabólicos, Enfermedad renal crónica, Hipercalcemia, Vitamina D, Suplementos vitamínicos |
| url |
http://www.sciencedirect.com/science/article/pii/S2013251420300237 |
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