6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine

6-Bromo-<i>N</i>-(2-methyl-2<i>H</i>-benzo[<i>d</i>][1,2,3]triazol-5-yl)quinolin-4-amine

We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2<i>H</i>-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement a...

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Bibliographic Details
Main Authors: Christopher R. M. Asquith, Graham J. Tizzard
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molbank
Subjects:
2-methyl-2<i>h</i>-1,2,3-triazole
4-anilino-quin(az)olines
conformational flexibility
hinge binder
kinase inhibitor design
Online Access:https://www.mdpi.com/1422-8599/2019/4/M1087
Description
Summary:We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2<i>H</i>-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with <sup>1</sup>H/<sup>13</sup>C-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS).
ISSN:1422-8599

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