Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression

Immune Checkpoints: Novel Therapeutic Targets to Attenuate Sepsis-Induced Immunosuppression

Sepsis is a leading cause of death in intensive care units and survivors develop prolonged immunosuppression and a high incidence of recurrent infections. No definitive therapy exists to treat sepsis and physicians rely on supportive care including antibiotics, intravenous fluids, and vasopressors....

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Main Authors: Margaret A. McBride, Tazeen K. Patil, Julia K. Bohannon, Antonio Hernandez, Edward R. Sherwood, Naeem K. Patil
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
sepsis
immunosuppression
T lymphocyte
myeloid cell
immune checkpoints
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.624272/full

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