Modeling Microarray Data: Interpreting and communicating the biological results

• Main Authors: Pittelkow Y. E., Wilson S. R.
• Format: Article
• Language: English
• Published: De Gruyter 2006-12-01
• Series: Journal of Integrative Bioinformatics
• Online Access: https://doi.org/10.1515/jib-2006-29

Various statistical models have been proposed for detecting differential gene expression in data from microarray experiments. Given such detection, we are usually interested in describing the differential expression patterns. Due to the large number of genes that are typically analysed in microarray experiments, possibly more than ten thousand, the tasks of interpretation and communication of all the corresponding statistical models pose a considerable challenge, except perhaps in the simplest experiment involving only two groups. A further challenge is to find methods to summarize the resulting models. These challenges increase with experimental complexity.