Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains

Herein, we assayed the antioxidant and anti-inflammatory potential of caffeine in a lipopolysaccharide (LPS)-injected mouse model of neurodegeneration and synaptic impairment. For this purpose, LPS was injected for two weeks on an alternate-day basis (250 µg/kg/i.p. for a total of seven dos...

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Bibliographic Details
Main Authors: Haroon Badshah, Muhammad Ikram, Waqar Ali, Sareer Ahmad, Jong Ryeal Hahm, Myeong Ok Kim
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Biomolecules
Subjects:
lps
oxidative stress
neurodegeneration
caffeine
neuroprotection
Online Access:https://www.mdpi.com/2218-273X/9/11/719

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