Association between EBV serological patterns and lymphocytic profile of SjS patients support a virally triggered autoimmune epithelitis

Association between EBV serological patterns and lymphocytic profile of SjS patients support a virally triggered autoimmune epithelitis

Abstract Sjögren's syndrome (SjS) is characterized by lymphocytic infiltration of exocrine glands, i.e. autoimmune epithelitis. Lymphocytes are central in SjS pathogenesis, with B-cell hyperactivity mediated by T-cells. B-cells are main targets of Epstein-Barr virus (EBV) infection, a frequentl...

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Bibliographic Details
Main Authors: Filipe Barcelos, Catarina Martins, Ricardo Monteiro, Joana Cardigos, Tiziano Prussiani, Miguel Sítima, Nuno Alves, José Vaz-Patto, Jaime Cunha-Branco, Luís-Miguel Borrego
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83550-0

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https://doi.org/10.1038/s41598-021-83550-0

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