Extração de ácido trans-trans mucônico urinário com polímeros de impressão molecular e análise por cromatografia gasosa: espectrometria de massas

• Main Authors: Lidiane Silva Franqui, André Coutinho Vieira, Patrícia Penido Maia, Eduardo Costa Figueiredo
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2012-01-01
• Series: Química Nova
• Subjects: trans, trans-muconic acid; molecularly imprinted polymers; gas chromatography
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000800016&lng=en&tlng=en
• ISSN: 1678-7064

This paper describes selective molecularly imprinted solid-phase extraction of ttMA from urine samples followed by derivatization and analysis by gas chromatography/mass spectrometry (GC/MS). The analytical calibration curve ranged from 0.3 to 7.0 mg L-1 (r = 0.999) and the limit of quantitation (LOQ) was 0.3 mg L-1. The method was applied for the determination of ttMA in urine samples from smokers and concentrations detected ranged from < LOQ to 1.64 mg L-1. Thus, the proposed method proved adequate for the determination of urinary ttMA in the biomonitoring of occupational exposure to low levels of benzene.