Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity

Downregulation of Endothelial Plexin A4 Under Inflammatory Conditions Impairs Vascular Integrity

Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are emerging as regulators of atherosclerosis, we set out to investigate the expression and function of inflammation-regulated NGC...

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Main Authors: Dianne Vreeken, Caroline Suzanne Bruikman, Wendy Stam, Stefan Martinus Leonardus Cox, Zsófia Nagy, Huayu Zhang, Rudmer Johannes Postma, Anton Jan van Zonneveld, Gerard Kornelis Hovingh, Janine Maria van Gils
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
neuroimmune guidance cues
plexin
semaphorin
inflammation
endothelial function
atherosclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.633609/full

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