In vivo anti-inflammatory, analgesic and antipyretic activities of novel thiazolidine-2,4-dione analogs derived from some classical NSAIDs

In vivo anti-inflammatory, analgesic and antipyretic activities of novel thiazolidine-2,4-dione analogs derived from some classical NSAIDs

In an attempt to develop selective inhibitors for the cyclooxygenase-2 enzymes as candidates for drugs to treat inflammation and pain, two thiazolidine-2,4-dione analogs were designed and synthesized, (E)-5-(4-isobutylbenzylidene)thiazolidine-2,4-dione (AW 01) and (E)-5-(2-hydroxybenzylidene)thiazol...

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Bibliographic Details
Main Authors: Wantana Reanmongkol, Chalermkiat Songkram
Format: Article
Language:English
Published: Prince of Songkla University 2013-02-01
Series:Songklanakarin Journal of Science and Technology (SJST)
Subjects:
thiazolidine-2
4-dione analogs
inflammation
pain
fever
experimental animal models
Online Access:http://rdo.psu.ac.th/sjstweb/journal/35-1/35-1-33-40.pdf

Internet

http://rdo.psu.ac.th/sjstweb/journal/35-1/35-1-33-40.pdf

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