Low‐Dose Tamoxifen Induces Significant Bone Formation in Mice

Low‐Dose Tamoxifen Induces Significant Bone Formation in Mice

ABSTRACT Use of the selective estrogen receptor modulator Tamoxifen (TAM) is a mainstay to induce conditional expression of Cre recombinase in transgenic laboratory mice. To excise β‐cateninfl/fl in 28‐day‐old male and female Prrx1‐CreER/β‐cateninfl/fl mice (C57BL/6), we utilized TAM at 150 mg/kg; d...

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Bibliographic Details
Main Authors: Zhihui Xie, Cody McGrath, Jeyantt Sankaran, Maya Styner, Sarah Little‐Letsinger, Amel Dudakovic, Andre J vanWijnen, Janet Rubin, Buer Sen
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:JBMR Plus
Subjects:
CONDITIONAL KNOCKOUT
OSTEOCLAST
μCT
Online Access:https://doi.org/10.1002/jbm4.10450

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